Circadian Pattern in Restless Legs Syndrome: Implications for Treatment Posology

Circadian Pattern in Restless Legs Syndrome: Implications for Treatment Posology

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The symptoms of restless legs syndrome (RLS) follow a circadian pattern, as inducated in the current RLS diagnostic criteria.Indeed, subjects with mild-to-moderate RLS suffer or not from RLS symptoms depending on the time carolina force softball of day, resembling an above-threshold state periodically followed by a below-threshold state.Although the circadian clock is crucial in the clinical features of RLS, research assessing the ultimate drivers of circadian rhythmicity is still very limited.In the present review, we show current evidence on circadian variations of neurotransmitters involved midnight drive nail polish in the pathophysiology of RLS (systemic iron metabolism, brain iron homeostasis, adenosine, dopamine, glutamate, and endogenous opioids).

Secondly, an overview of available therapies for RLS is presented, including information on current recommendations for symptomatic treatments in RLS.